Unreal has recently announced the port of the Unreal Engine 3 on Mac OS X! => http://udn.epicgames.com/Three/MacPlatformHome.html

And Virtual Programming is supporting this initiative behind the scenes, if to believe their recent blog post. They have undertaken the actual port for Epic: Congratulations guys! We just can’t wait to see which new RTS, FPS, MMOGs and simply wargames are going to be created on our preferred platform and OS
